Polycystic liver disease (PLD) is a genetic condition in which numerous cysts form in the liver, causing the organ to enlarge and potentially leading to complications such as infections or obstruction of bile ducts. Synonyms for PLD include hepatic cystic disease, autosomal dominant polycystic liver disease (ADPLD), and cystic liver disease. Another related condition is autosomal dominant polycystic kidney disease (ADPKD), which involves cysts forming in the kidneys as well as the liver. Treatment for PLD may involve managing symptoms such as pain or discomfort, or in severe cases, surgery to remove the affected portion of the liver.